Integrity

Danielle Shingleton Exemplification essay 10/3/10 Integrity We are presented with choices every day. Many are easy to make and cause very little stress, but some choices can be extremely difficult and have significant consequences. The difference between making the right choice or the wrong one is often determined be a persons character, which is based upon the qualities of integrity, responsibility, and honesty. Gaining an understanding of these three character traits and how to build them is critical to creating a lifetime of positive outcomes. Honesty is the quality or fact of being honest.Finding a pen off the floor and giving it to a teacher is honesty. Not keeping the pen was respectful and honest, in order to reach self actualization and have integrity, you have to have needs met like food and water, love and care from friends and family, especially self confidence. Honesty means basing one’s actions on an internally consistent outline of principles. Depth of principles and devotion of each level to the next are key determining factors. One said to have integrity to the extent that everything they do and believe is based on the same core set of values.While those values may change, it is their consistency with each other and with the person’s actions that determine their integrity. The concept of integrity is directly linked to responsibility. Responsibility is acknowledging that you are solely responsible for the choices in your life. Taking on a job while still in high school and maintain good grades if very possible. Accepting that you are responsible for what you choose to feel or think. Accepting that you cannot blame others for the choices you have made.And protecting and nurturing your health and emotional well being. When a person is trustworthy, he or she can be relied upon to be honest, reliable, and loyal which means they have integrity. But its equally important to be respectful, responsible, fair, caring, and demonstrate good c itizenship. Good citizenship can be viewed in many ways. Hitler viewed his actions as reliable, honest, fair, and thought he was demonstrating good citizenship by eliminating a different race. The Nazis saw Hitler as a man with integrity. We saw Hitler as a cruel unfair man without integrity.Good character and integrity are easiest to demonstrate when facing public disapproval, but the true test comes when you can potentially get away with anything because then nothing is at stake but your own conscience. Trustworthy is very similar to truthfulness, uprightness, and honor. Truthfulness is when a person consistently tells the truth, and is honest. Honor is the equality of being honorable, and to show respect for others. These simple but powerful words are components of integrity. A person of integrity does exactly what he says and says exactly what he means.There is no conflict between his thoughts and actions. His actions are consistent with the values he professes. According to Dr. William Manninger, A building without integrity may receive structural damage, or even collapse, in a storm. Similarly, people without integrity are blown about by the winds of misfortune and destroyed by catastrophes, for they lack the firmness, solidity, and strength of character to weather any storm. This means that integrity is one of the six essential qualities that are the key to success. The other five are sincerity, humility, courtesy, wisdom, and charity.Integrity is about doing what is right rather than what is appropriate. Not everyone has integrity; the family life has a major impact on a person’s values and principles. When you have integrity you know it as much as everyone else around you does. Just because someone makes a few simple mistakes here and there doesn’t mean they have no integrity. Low integrity is when people get punished, they feel guilty, and lose respect from family and friends. You have a bad reputation, your actions result in problems, accidents, injuries, even death.You also get other people into trouble, by blaming everyone else but yourself. There are benefits to having high integrity, such as; being happy and making other people happy, you have peace of mind, and no guilt feelings. You feel good or satisfied at having done the right thing. As you gain respect from family and friends, you may become an inspiration to others. A person with integrity will have the courage to say no. Have the courage to face the truth. Do the right thing it is right. These are the magic keys to living your life with integrity. it’s not what we eat but what we digest that makes us strong; not what we gain but what we save that makes us rich; not what we read but what we remember that makes us learned; and not what profess but what we practice that gives us integrity. † â€Å"A person is not given integrity. It results from the relentless pursuit of honesty at all times. † â€Å"Living with integrity mean: Not s ettling for less than what you know you deserve in your relationships. Asking for what you want and need from others. Speaking the truth, even though it might create conflict or tension. Behaving in ways that are harmony with your personal values.Making choices based on what you believe, and not what other believes. † You cannot become â€Å"Integridized† in one day. In order to have integrity, you have to go through milestones in your life. No one can persuade you to become integridized. It’s all personal beliefs and doing the right thing. The majority of integrity comes from the home life. Family and friends play a major role in a person’s life. Being though the right things and to be honest and have goals and be true will have more integrity in life than anyone else. Let’s say one day you find one hundred dollars in your school.Would you keep it, or would you hand it to the teacher? You don’t lie, and you are reliable. You can always be de pended on you are trustworthy; people are able to put their trust in you. That is integrity, by not keeping the money and turning it in. That little person talking to you in the back of your head telling you turn it in is part of having integrity! According to Mark D. Rasche, in his Biblical Integrity days of praise article, â€Å"let integrity and uprightness preserve me; for I wait on thee. † â€Å"Some have said that integrity can be measured by what a person does when no else is looking.While this may be an indicator of integrity, it is not the real litmus test. According to scripture, the true gauge of a man’s integrity is his heart. The worlds evaluates a person’s integrity from hat it see’s in a man’s outward behavior. God judge’s integrity from what he sees in a man’s heart, for â€Å"every way of a man is right in his own eyes: but the Lord pondered the hearts†. In other words, man measure integrity from the outside, and God measure integrity from the inside. † I truly believe integrity is not lost in America. Integrity is not found on the surface you have to dig deep within in to uncover it.You hear all the time people saying the, â€Å"There are no men of integrity left. † This is not true. Men and women of integrity are everywhere. Think about this, how many people pass your car, house, and your place of business each day and do not steal from it? We spend too much time focusing on people without integrity and we forget to celebrate and show gratitude to those who do what is right every day. What you focus you attention and actions on you will receive. If you search the world for examples of people failing you will find all the examples you are looking for.The same is true for those that seek examples of integrity. If you focus your attention on discovering people that do what is right you will find integrity everywhere you look. You might not have to look very far to find what y ou are searching for. Chances are you will only need to look inside yourself. Yourself improvement blog, article: the most important trait of successful people! States that â€Å"a life lived with integrity-even if it lacks the trappings of fame and fortune is a shining star in whose light others may follow in the years to come† says author of article Denis Waitley Integrity Danielle Shingleton Exemplification essay 10/3/10 Integrity We are presented with choices every day. Many are easy to make and cause very little stress, but some choices can be extremely difficult and have significant consequences. The difference between making the right choice or the wrong one is often determined be a persons character, which is based upon the qualities of integrity, responsibility, and honesty. Gaining an understanding of these three character traits and how to build them is critical to creating a lifetime of positive outcomes. Honesty is the quality or fact of being honest.Finding a pen off the floor and giving it to a teacher is honesty. Not keeping the pen was respectful and honest, in order to reach self actualization and have integrity, you have to have needs met like food and water, love and care from friends and family, especially self confidence. Honesty means basing one’s actions on an internally consistent outline of principles. Depth of principles and devotion of each level to the next are key determining factors. One said to have integrity to the extent that everything they do and believe is based on the same core set of values.While those values may change, it is their consistency with each other and with the person’s actions that determine their integrity. The concept of integrity is directly linked to responsibility. Responsibility is acknowledging that you are solely responsible for the choices in your life. Taking on a job while still in high school and maintain good grades if very possible. Accepting that you are responsible for what you choose to feel or think. Accepting that you cannot blame others for the choices you have made.And protecting and nurturing your health and emotional well being. When a person is trustworthy, he or she can be relied upon to be honest, reliable, and loyal which means they have integrity. But its equally important to be respectful, responsible, fair, caring, and demonstrate good c itizenship. Good citizenship can be viewed in many ways. Hitler viewed his actions as reliable, honest, fair, and thought he was demonstrating good citizenship by eliminating a different race. The Nazis saw Hitler as a man with integrity. We saw Hitler as a cruel unfair man without integrity.Good character and integrity are easiest to demonstrate when facing public disapproval, but the true test comes when you can potentially get away with anything because then nothing is at stake but your own conscience. Trustworthy is very similar to truthfulness, uprightness, and honor. Truthfulness is when a person consistently tells the truth, and is honest. Honor is the equality of being honorable, and to show respect for others. These simple but powerful words are components of integrity. A person of integrity does exactly what he says and says exactly what he means.There is no conflict between his thoughts and actions. His actions are consistent with the values he professes. According to Dr. William Manninger, A building without integrity may receive structural damage, or even collapse, in a storm. Similarly, people without integrity are blown about by the winds of misfortune and destroyed by catastrophes, for they lack the firmness, solidity, and strength of character to weather any storm. This means that integrity is one of the six essential qualities that are the key to success. The other five are sincerity, humility, courtesy, wisdom, and charity.Integrity is about doing what is right rather than what is appropriate. Not everyone has integrity; the family life has a major impact on a person’s values and principles. When you have integrity you know it as much as everyone else around you does. Just because someone makes a few simple mistakes here and there doesn’t mean they have no integrity. Low integrity is when people get punished, they feel guilty, and lose respect from family and friends. You have a bad reputation, your actions result in problems, accidents, injuries, even death.You also get other people into trouble, by blaming everyone else but yourself. There are benefits to having high integrity, such as; being happy and making other people happy, you have peace of mind, and no guilt feelings. You feel good or satisfied at having done the right thing. As you gain respect from family and friends, you may become an inspiration to others. A person with integrity will have the courage to say no. Have the courage to face the truth. Do the right thing it is right. These are the magic keys to living your life with integrity. it’s not what we eat but what we digest that makes us strong; not what we gain but what we save that makes us rich; not what we read but what we remember that makes us learned; and not what profess but what we practice that gives us integrity. † â€Å"A person is not given integrity. It results from the relentless pursuit of honesty at all times. † â€Å"Living with integrity mean: Not s ettling for less than what you know you deserve in your relationships. Asking for what you want and need from others. Speaking the truth, even though it might create conflict or tension. Behaving in ways that are harmony with your personal values.Making choices based on what you believe, and not what other believes. † You cannot become â€Å"Integridized† in one day. In order to have integrity, you have to go through milestones in your life. No one can persuade you to become integridized. It’s all personal beliefs and doing the right thing. The majority of integrity comes from the home life. Family and friends play a major role in a person’s life. Being though the right things and to be honest and have goals and be true will have more integrity in life than anyone else. Let’s say one day you find one hundred dollars in your school.Would you keep it, or would you hand it to the teacher? You don’t lie, and you are reliable. You can always be de pended on you are trustworthy; people are able to put their trust in you. That is integrity, by not keeping the money and turning it in. That little person talking to you in the back of your head telling you turn it in is part of having integrity! According to Mark D. Rasche, in his Biblical Integrity days of praise article, â€Å"let integrity and uprightness preserve me; for I wait on thee. † â€Å"Some have said that integrity can be measured by what a person does when no else is looking.While this may be an indicator of integrity, it is not the real litmus test. According to scripture, the true gauge of a man’s integrity is his heart. The worlds evaluates a person’s integrity from hat it see’s in a man’s outward behavior. God judge’s integrity from what he sees in a man’s heart, for â€Å"every way of a man is right in his own eyes: but the Lord pondered the hearts†. In other words, man measure integrity from the outside, and God measure integrity from the inside. † I truly believe integrity is not lost in America. Integrity is not found on the surface you have to dig deep within in to uncover it.You hear all the time people saying the, â€Å"There are no men of integrity left. † This is not true. Men and women of integrity are everywhere. Think about this, how many people pass your car, house, and your place of business each day and do not steal from it? We spend too much time focusing on people without integrity and we forget to celebrate and show gratitude to those who do what is right every day. What you focus you attention and actions on you will receive. If you search the world for examples of people failing you will find all the examples you are looking for.The same is true for those that seek examples of integrity. If you focus your attention on discovering people that do what is right you will find integrity everywhere you look. You might not have to look very far to find what y ou are searching for. Chances are you will only need to look inside yourself. Yourself improvement blog, article: the most important trait of successful people! States that â€Å"a life lived with integrity-even if it lacks the trappings of fame and fortune is a shining star in whose light others may follow in the years to come† says author of article Denis Waitley

Spending Habits of Students

What are the possible solutions that students must do to overcome/to control their spending habits? What is the main factor that affects the students spending habits? Introduction: Spending money is a habitual work of people, it can't be avoid because our world is full of price tag, but every stage of a person has its own habits in spending money. In this research, students will be the main topic in spending money.One day millionaire!!! That is how students practice their spending habits. These habits developed mostly during college. By then, students receive bigger allowance from their parents. This is the time when young men and women start to make decisions on their own. Students all over the world spend in several different ways; most students prioritize their school needs rather than their wants which affect their spending habits.What can be the possible solutions for the students to overcome or to control their spending habits? What can be the main factor that affects the stude nts spending habits? Students must learn how to handle their finances. They have to know the value of money even in its little amount. They have to develop positive spending habit; otherwise, it will be a future problem for him/her because he/she spends the money In an incorrect way.

A Study on Accounting Software

Every business needs to keep a track of its expenses and profits as well as payments. But, since every business is unique their needs within accounting software also differs. Before the new millennium, most small businesses handled their accounts using paper based accounting systems which worked fine. The introduction of Goods and Service Taxes changed the lookout of the businesses that earlier used to keep their accounting through paper only. Most businesses shifted to accounting software’s, and one of the most popular ones online is the Intuit Quickbooks. The software that helps accountants and bookkeepers keep all the transactions managed at one place without having the need to spend extra effort.   QuickBooks was one of the primary accounting software items available, and numerous organizations still depend on it today. Be that as it may, as of late, bookkeeping/accounting software has started to move to the online circle, keeping in mind the move is a long way from complete (cloud accounting still hasn't got up to speed with the element choice accessible in great privately introduced programs), it's not hard to see which way the wind is blowing  (Broughton, 2008). Intuit's QuickBooks is a standout amongst the most well-known accounting software utilized by Australian small entrepreneurs. There are two key variables adding to QuickBooks' prominence as a top small business accounting software in Australia. The first is its cost. You can pay $12/month (deal cost) for QuickBooks' most essential software and a maximum of $21/month (deal cost) for the head variant. The second component is the far reaching level of features that QuickBooks gives. Entrepreneurs crosswise over Australia use QuickBooks to track their business salary, costs, and benefits. They can send a boundless measure of invoices, get to their information online over an extensive variety of portable and desktop stages (PC, Mac, tablet, or cell phone), oversee/pay bills, and make finance installments for nothing. For security, QuickBooks has quite the same security and encryption as leading banks. The above variables are only a couple features that accompany Intuit's QuickBooks  (Bi afore, 2012). Intuit Inc. was established in 1983 as the distributer of Quicken, a MS-DOS monetary administration framework for people. Animate's prosperity prompted a large group of subsequent items, including QuickBooks, which was propelled in 1992 and rapidly turned into the business' top small-business accounting arrangement. Intuit depicts QuickBooks as the foundation of its "small business environment," a business sector that records for a noteworthy offer of the organization's $3.9 billion in yearly incomes. It is effectively the top rated retail software for small-business accounting around the world  (Biafore, 2015). The principal program from Intuit, called Quicken, was intended for individual budgetary administration. It was extraordinarily fruitful and prompted the improvement of a comparative system for small organizations. The explanation behind its prevalence among entrepreneurs is on the grounds that it required no formal accounting preparing. In any case, after a few worries from accounting experts about the project's absence of a review trail and not complying with conventional accounting rules, Intuit grew new programs that tended to these worries. The new programs included review trail capacities and also twofold passage accounting capacities and other new features. The Basic and Pro forms of Quicken accounting software bundles were produced in 2000. This was trailed by the improvement of industry particular adaptations in 2003. These programs contemplated the work process procedures and wording utilized as a part of particular ventures. 2002 saw the dispatch of QuickBooks Enterprise S olutions, which was intended for medium-size organizations. Over the accompanying couple of years, new forms of the software QuickBooks were made that could be utilized as a part of various areas of the world  (Ullah, 2013). Notwithstanding supporting various stages, Intuit offers distinctive capabilities at various value focuses. QuickBooks for Windows, for instance, is accessible in Pro, Premier, and Enterprise editions. Specific editions are accessible for accounting, contracting, assembling and wholesale, philanthropies, proficient administrations, and retail organizations. Moreover, every item might be obtained on CD or by means of subscription. Subscribers get new features as they are produced, while CD clients don't get the new features until they move up to another arrival of the software  (Gardon, 2005). The permit key methodology implies Intuit can redesign clients or permit particular renditions of the software with a straightforward online transaction. It likewise has huge ramifications for SCM. The advantage is that we're continually expanding and refining a solitary codebase for Quickbooks. The engineers don't need to stress such a great amount over keeping up similarity among numerous renditions of the item. The drawback is that a full form takes off numerous, numerous adaptations of the item. It's a gigantic form  (Group, 2005). Intuit QuickBooks works in the small business market, sized at roughly 29 million businesses in the US, and it has more than 80% piece of the pie with small businesses that utilization monetary administration software. With the objective of helping a greater amount of these small businesses enhance their monetary lives, administration executed profoundly focused on and creative client division and business sector systems. QuickBooks has since quite a while ago distinguished two essential fragments of small businesses: The 400,000 accountants who are serving a large number of small businesses as the key influencers & also the five million small businesses as of now utilizing money related administration software. This left 15 million other independently employed people who have the chance to accomplish more business with QuickBooks or turn out to be new clients. These clients are portrayed by an easygoing way to deal with their money related administration, numerous seeing their small business as a leisure activity or low maintenance try. By the process of deliberately dividing its clients, QuickBooks has possessed the capacity to create particular business sector techniques to develop potential in every fragment. Addressing the need of accounting software, Intuit made QuickBooks Online Self-Employed, a simple to-use application that helps clients track pay, download costs and get ready for both quarterly and year-end assesses, all while meeting consistence prerequisites. This application goes past intangibility by adding a touch of gamification to the information passage process—for instance, clients can order costs by swiping left for operational expense and a good fit for individual. At $8/month, it's an economical passage point for clients that may, one day, require the more hearty features of QuickBooks Online  (Salmon, 2014). By effectively gathering information and arranging it, QuickBooks Online Self-Employed additionally permits clients to all the more effortlessly bear the cost of an accountant. Boxes of receipts are supplanted with information that is sorted out and effortlessly imparted to an accountant. Presently, QuickBooks ProAdvisors can serve these customers moderately, and it makes another business sector open door for everybody. How about we swing to the ProAdvisor project to perceive how QuickBooks supports referrals  (Ullah, 2013). More than a modest bunch of online software items with names like FreshBooks, Xero and Saasu have ended up as eminent QuickBooks contenders by concentrating on ease of use, cost and different components. The genuine inquiry is would they say they are sufficiently distinctive to make it worth your time and push to assess them before settling on a choice or is there truly much contrast between these choices and how they help businesses deal with their books and receipts of their clients. Here are the top contenders. Xero is a finished web-hosted accounting software arrangement which gives QuickBooks Online a keep running for its cash. Like most cloud software, Xero is offered in a SaaS model, which costs $9 to$70/month, contingent upon the features and number of clients you require. Clients likewise like Xero's day in and day out client backing and plenty of mixes with different business software. Some of the numerous features you get with Xero incorporate evaluations, invoicing, creditor liabilities, reporting, inventory administration, cost reports, finance, bank compromise, and time  (Broughton, 2008) Established 15 years prior, Saasu was one of the main cloud-based accounting software administrations around. Saasu is fundamentally intended for the Australian business sector, however it could work for small US organizations who work together in standout state and need extraordinary inventory support. Some of Saasu's best features are its adjustable dashboard and amazing inventory instruments (particularly the "combo thing" highlight). Saasu's inventory features are really the best we've found in any cloud-based accounting software, anyplace. In synopsis in the event that you have not switched to electronic or software accounting you ought to genuinely consider doing as such. Intuit Quickbooks is software that can help any small to medium business accounting less demanding than some time recently. Among the best accounting software bundles available, Quickbooks is the best. Among the main softwares, Quickbooks offers the best general bundle. It additionally offers free trial alternatives and it can be effectively downloaded from the intuit website or introduced from the album gave. There are different subscription administrations one can use according to the features they require. Generally speaking, it is accounting software one can use for their small and medium business unquestionably.   Biafore, B., 2012. QuickBooks 2013: The Missing Manual: The Official Intuit Guide to QuickBooks 2013. s.l.:"O'Reilly Media, Inc.". Biafore, B., 2015. Answers found here, s.l.: QuickBooks . Broughton, J., 2008. Wikipedia: The Missing Manual: The Missing Manual. s.l.:"O'Reilly Media, Inc.". Gardon, A., 2005. Strategies for Change. JOURNAL for Nonprofit Management, 5(4), pp. 1-58. Group, S., 2005. Learning QuickBooks Step-by-Step - Using QuickBooks Payroll - Version 2005. s.l.:The Sleeter Group. Salmon, A., 2014. Accounting Software, s.l.: Accounting Market Changes. Ullah, H., 2013. Job Development for Today - A Sector Specific Approach. The Canadian Journal of Career Development, 5(1), pp. 1-9.

British Television Comedy Essay Example | Topics and Well Written Essays - 1500 words

British Television Comedy - Essay Example Negative health effects can become evident if a person sits around the house all day watching TV. But is there anything positive that can be said about television? Educational programs are believed to be a positive element ÃŽ ¿f television, since those watching will learn from the show. Television is also viewed as being a way for anyone to connect to the world. Basically, television allows us to gain knowledge about events occurring in China, Brazil, and all around the world. Television allows us to communicate with each other. And ÃŽ ¿f course, the main positive aspect ÃŽ ¿f television is that it provides us with entertainment. Feeling bored with nothing to do? Turn on the TV for a half hour and enjoy your favourite television show. As you can see, there are both positive and negative effects associated with television. But no matter what anyone says, one thing is clear: television is here to stay. The technology keeps getting better, as more and more channels become available to us. Television ratings today are higher than ever. People are tuning in, and television is a part ÃŽ ¿f almost everyones life. Violence on TV effects people, especially children, in negative ways. Before the average American child leaves elementary school, researchers estimate that he or she will have witnessed more than 8,000 murders on television. Nearly 3,000 studies have found a connection between television violence and real violence. For example, studies involving children show that the more violence a child watches on TV, the more violent he or she will act. People that watch TV are influenced by what they watch. For example, a person might watch a man swearing on television, and then they use the same swear words as the person on television did. Or a young girl might watch a show in which all ÃŽ ¿f the main characters are skinny, and because ÃŽ ¿f this she might want to make herself thinner, endangering her health in the process. Some people become addicted to TV. They watch

What strategic influence does Special Operations have Research Paper

What strategic influence does Special Operations have - Research Paper Example This research aims at analyzing the nature and the characteristics of special operations and the strategic influence that they have on the target population. Special operations demand the use of special methods of employment, special techniques, tactics, procedures as well as equipment. Special operations acquire significance in harsh environments characterized by high level of hostility, denial and environments that are most sensitive politically or diplomatically. These operations are thus more time sensitive and concealed in nature. Special operations according to Derek (2006, 149) have lower visibility, work in collaboration with local forces and require greater regional point of reference as well as cultural proficiency. Special operations require very high level of intelligence and the intelligence organ must have a good understanding of the major activities. It must be capable of approving all the logistical requirements within the shortest time possible, which is usually within a span of fifteen days. The communication system has to be significantly efficient to ease collection of information from the ground as well as coordination within the staff members involved to arrive at the best solution for the prevailing situation. In operating in remote areas, according to Derek (2006, 252) special operations mostly require the use of long range and surface oriented combined firing support. With special operations, offensive actions can be either by seizing the core facilities of the people as a piece of the wide operation or utilizing a guerilla war tactic of hitting and running away to cool the chosen targets. Even though the other ordinary units are capable of carrying out such operations, special units perform with greater precision thus yielding better results. Special Forces are also capable of conducting such operations in areas where the other ordinary units cannot reach. A common characteristic of special operations is effectiveness in terms

Newton's laws Essay Example | Topics and Well Written Essays - 1250 words

Newton's laws - Essay Example Newton's laws of motion (law of inertia, fundamental law of dynamics, law of reciprocal actions) were verified by experiment and observation for over 200 years, and they are excellent approximations at the scales and speeds of everyday life. At the atomic scale, they become a poorer approximation to quantum mechanics, and at speeds comparable to the speed of light, they become a poorer approximation to relativity. Just as they fail for material objects moving at speeds close to the speed of light, they fail for light itself. Newton's first law appeared to be in the past just a special case of the second law, and it was thought Newton stated the first law separately simply in order to throw down the gauntlet to the Aristotelians. However, modern physicists think that the First Law defines the reference frames in which the other two laws are valid. These reference frames are called inertial reference frames or Galilean reference frames, and are moving at constant velocity, that is to say, without acceleration. (Note that an object may have a constant speed through its motion path and yet have a non-zero acceleration, as in the case of uniform circular motion. This means that the surface of the Earth is not an inertial reference frame, since the Earth is rotating on its axis and orbits around the Sun. However, for many experiments, the Earth's surface can safely be assumed to be inertial. The law of gravity became Sir Isaac Newton's best-known discovery. Newton warned against using it to view the universe as a mere machine, like a great clock.

Human sexuality Essay Example | Topics and Well Written Essays - 250 words - 1

Human sexuality - Essay Example enarios and the brain ability to mould it self is similar to plastic’s ability to change shape according to elements and objects that contacts the plastic. According to Doidge, a child’s brain has the ability to change over time with changes in environment (Doidge 98). He further states that when children are experiencing adolescent period, they should not be labeled according to their current sexuality preference as this preference changes over time until finally a sexual orientation becomes permanent. The book further states that there is a direct link between culture and brain and brain experiences alterations due to culture and not due to genes. This means that when the brain comes in contact with certain cultural practices, it adopts it and the individual starts behaving accordingly. The concept that brain is adaptive to environment can help us achieve our aims and objectives and we can alter our brain according to our needs. In relation to human sexuality an indiv idual can control his/her sexuality. If the individual wants to be labeled as straight then he/she should come in contact with their opposite sex and this will adapt the brain towards that sex and sexual

Discrimination Law Essay Example | Topics and Well Written Essays - 2500 words

Discrimination Law - Essay Example Sex inequality issues in the United Kingdom By assigning the recognition of â€Å"protected characteristic† to sex as a criterion for maintaining equality in the United Kingdom, the Equality Act 2010 complicates issues in several ways. The history of inequality with regard to sex in the UK has spanned decades, and still evolving. It is such a complex matter that could not be easily rectified through the mere reform of the UK discrimination law. The following examples demonstrate why sex inequality is such an endemic crime in the United Kingdom. Though progress has been recorded recently in every facet of UK public life, however, the society is still largely dominated by males (Coveney et al., 1984). There are reports of gender inequality in education all across the UK (Riddell and Salisbury, 1999). 2 Male dominance has become ingrained into the UK society that it seems it is just the natural thing to do. It is a known fact that discriminating against women in terms of educatio n (as it was done many years before) has a far-reaching impact on the womenfolk. First, it makes women to be unequal with men in knowledge acquisition and subsequently turns them into unqualified people. This trend had made it impossible to find women who were as qualified as men to take up challenging positions in both private and public offices. Although things have changed drastically in this modern dispensation, but there are still disheartening reports that sex discrimination is still a viable problem in UK labour practices (Perlman and Pike, 1994). Employers look down on women and consider men for jobs based on different reasons. It is believed that most women do not maintain continuity in their jobs because of other responsibilities that include marriage, children-bearing and other domestic concerns; men, on the other hand, are regarded as strong and more professionally minded. Using these reasons to discriminate against women is not appropriate, but employers are mainly conc erned about the success of their businesses. If they are eventually employed, women still face serious issues of discrimination in their workplaces. There are indications that some UK companies offer better pensions and insurance benefits for their male workers than those given to their female employees (Perlman and Pike, 1994). Similarly, wages for male and female workers are not the same, even though they do the same amount of job at their respective workplaces. This 3 preferential treatment of male workers over female workers stems from the fact that United Kingdom’s industries were founded with a focus on males as the viable workforce (Mosley et al., 2002). And this perception has not changed much in this modern day as employers still dismissed female workers because of flimsy excuses like dating a fellow worker or getting pregnant during the peak work period (FL Memo Ltd., 2005). An interesting case to illustrate the tediousness of the male versus female tension in UK la bour markets is Webb v EMO Air Cargo (UK) Ltd, where Ms Webb was seeking claims for unfair dismissal based on her pregnancy. Those she was chastised for using the argument that if male workers could be allowed to treat themselves when they fell sick, why shouldn’t a pregnant woman be allowed to go for child-rearing; her employer (Air Cargo (UK) Ltd was criticised for firing her based on pregnancy, an action that was illegal and contravened the United Kingdom labour law (Collins et al., 2005). This

Different Forms of Corruption Essay Example | Topics and Well Written Essays - 2000 words

Different Forms of Corruption - Essay Example Why do these cases seem to appear to be more frequent in modern day sport than previously? An obvious answer is that there is so much more media coverage. It is perhaps as much a matter of perception than of fact. A hundred years ago a person either attended a sports event in person or else read about it in the newspaper after the event. Then came radio and film reports. In the 1930 outside broadcasts began from sporting events such as the Oxford /Cambridge boat race and football matches. Wimbledon was the first broadcast in 1937 and the Football Association Cup final the following year according to ‘The BBC Story’ (undated). Now in the 21st century, we have instant replays, coverage around the globe, and much more in the way of electronic and medical checks. Starting blocks in athletic races, for instance, can tell a split second when a runner leaves the blocks. An instant replay will show cheating that a referee and linesmen may have missed. There are also many more checks such as blood and urine tests which show up various prohibited substances – on occasions those taken inadvertently in such things as flu remedies. It is also possible to spot unusual betting patterns electronically. FIFA, for instance, has an Early Warning System GmbH ( 2011) which looks at betting patterns. None of these checks were present earlier so, if there was any corruption, it would have been much less obvious and harder to prove. Football – according to Sepp Blatter, FIFA president, in a report of May 2010, referees are a weak link when it comes to fighting corruption. So much so that before the 2006 World Cup referees had security guards posted at their hotels and were not allowed to take or make outside calls. Their fees have been increased as an incentive – so it almost looks like do wrong and be rewarded.  

Customer behavior summary about social media Essay

Customer behavior summary about social media - Essay Example We will therefore focus on these level of needs and how marketers can use them to their advantage. First are the physiological needs which are basically biological needs such as food, water, oxygen and shelter. Of all the needs, the physiological needs are the most important and basic and therefore, they should be satisfied first. In the social network sphere, the marketers can satisfy the customers’ physiological needs by finding out the information concerning nutrition and medicine of their existing and potential customers. The second level is composed of the safety or security needs which become active only after the physiological needs have been met. Whereas adults have usually little awareness of their safety needs apart from periods of emergency, children usually show signs of insecurity thereby prompting the need to be safe. Individuals can use social networks to update their status and inform security firms such as police and other authority of any insecurity or emergency. By doing this, the individuals’ safety needs are met appropriately. Thirdly, the needs of Love, affection and belongingness enables individuals to overcome the feelings of isolation and loneliness. These needs therefore comprises of both showing and receiving love and affection from others which one to have a sense of belonging. Through social networks such as Facebook, Twitter and Instagram, people are able to share love by commenting on statuses, liking pictures and even engaging in online dating. This actions reduces or eliminates the feeling of loneliness and alienation thus enabling them to attain the needs of love, affection and belongingness. Comparatively, after the first three needs have been met, an individual develops the needs for esteem which involve self-esteem and esteem for others. In this segment, an individual tends to have a high level of self-respect and therefore desires to have respect from others too. Through the social networking

The Viking Age Essay Example for Free

The Viking Age Essay The aim of this essay is to critically describe daily life in Viking Ireland in either Dublin or Waterford. For the purpose of this essay I will concentrate on Dublin, as there is a substantial amount of archaeological evidence that was found and excavated by archaeologists. It has been widely recognised from extensive archaeology excavations that Fishamble Street and Winetavern Street as well as High Street were pivotal centres in which the Vikings took residence and went about their daily life (Hall 1990, 25). This essay will look at many different aspects of Viking daily life in Dublin, including their occupational activity, the types of houses they lived in, their burials and the type of objects they traded on a regular basis. This essay will firstly deal with the houses and types of dwellings that the Vikings of Dublin were accustomed to. The major excavations that took place between the years 1961 and 1981 in the areas of Wood Quay and Christchurch (Rosedahl 1982, 229-230). The excavations reveal to us that the normal everyday Viking dweller lived in houses that were mostly composed of wattle and daub (Rosedahl 1982, 230). Other characteristics of the type of house a Dublin Viking would live in was that the shape would always be rectangular accompanied by rounded corners and end walls (Clarke and Simms 1985, 126). The majority of the houses also had small cubicles at either end of the main house. The presence of animal bone shows us that the people of Dublin ate meat. There have been thirteen levels of preservation located on Wood Quay. This has been dated to 920 A. D These houses once they are no use; are knocked down immediately and a new house is built on top of the old one (Rosedahl 1982, 231). People of Viking Age Dublin were very skilled and well-crafted trades people. Many Dublin craftsmen were highly skilled in areas such as the manufacture of bone and antler combs (Clarke and Simms 1985, 134). The bone that was excavated is known to be of the red deer (Rosedahl 1982, 231). These Dublin craftsmen also worked with leather, wooden objects such as the manufacture of ploughs, bone whorls and needles and pins. Archaeological evidence has also shown that the crafts of ship building, bone carving, carpentry and iron manufacture have taken place (Rosedahl 1982, 231). The majority of Viking men would have spent their own daily life manufacturing these and this would have probably been their main source of income. These craftsmen worked with not only the one style, but with many different ones. The Vikings of Dublin also manufactured broad arm rings. This would have mainly taken place for the circulation and storage if timber (Larsen 2001, 57-59). To illustrate the importance of amber working in Viking Age Dublin an amber workshop has been excavated. A wide range of objects have been uncovered including beads, pendants and rings (Clarke and Simms 1984, 136). For the most part they were highly influenced from outside sources (Hall 1990, 26). However the archaeological evidence of Dublin shows us that it was the metalworkers that were possibly one of the most common and important tradesmen. Tongs and hammers that were manufactured by smiths have been found in numerous burials in Kilmainham and Islandbridge (Hall 1990, 58). Also at a site known as Granby Row there have been other metal objects uncovered such as rivets, an iron spearhead and sword. Also two swords, four spearheads, a shield boss and a copper alloy buckle that was thinned were excavated at the College Green site OFloinn 1998, 134-135). Including these trades occupying the daily lives of those in Viking Dublin, there were other activities that were also taking place. Extensive archaeological evidence has been uncovered to suggest that there was a lot of trade and gift exchange taking place as well (Clarke and Simms 1984, 135). Such items that show this include pieces of porphyry from the Italian capital, an exotic ring made of gold that has a red garnet that appears to be Frankish. Also a carved boss made of wood was uncovered, whose origins are from the northern province of Ireland (Clarke and Simms, 135). This archaeological evidence also proves to us that the Vikings lead a reasonable wealthy life or perhaps a very wealthy life, as trading precious objects took place on a regular ongoing basis. In relation to Viking graves and burial customs, there are two main cemeteries in Dublin. These are that of Kilmainham and Island Bridge. It is known that there are 43 furnished burials in all. However Kilmainham is the largest with 30 furnished burials in all. With the substantial amount of grave goods present in both sites it should be said that the Dublin Vikings thought very much of their dead (Larsen 2001, 67). Weapons such as swords, daggers and other inflicting weapons tend to dominate the female graves (Larsen 2001,68). Also for craft and domestic use tanged knives and a range of different buckles have been uncovered, that people used to keep their clothes on. However the most elaborate and decorative item found was that of the Kilmainham brooch (Larsen 2001, 72). It is widely thought that this item is definitely the single richest Viking Age grave good from an Irish context (Larsen 2001, 72). In conclusion this essay has discussed, analysed and described Viking daily life in Dublin. By using the appropriate archaeological evidence one can see how the Vikings of Dublin went about their routine on a daily basis. Also the main themes that this essay has included are that of the Vikings crafts that they done to make a living. This essay also looked at the type of houses, by taking into consideration their size and shape. When writing this essay I also looked at trade and the type of goods that the Dublin Vikings traded and treasured. Through excellent preservation of Viking graves at Islandbridge and Kilmainham this essay took a brief look at Viking graves and what their attitude was to what goods should be buried with males and females. Bibliography Hall, R. 1990. Viking Age Archaeology in Britain and Ireland. Princes Risborough. Larsen, Anne-Christine, 2001. The Vikings in Ireland Roskilde, The Viking Ship Museum. Rosedahl, E.1992. The Vikings. Harmondsworth. Wallace, P. 1985. The Archaeology of Viking Dublin. In H.B. Clarke A. Simms (eds) The Comparative History of Urban Origins in Non-Roman Europe.

Operations Decision Essay Example for Free

Operations Decision Essay This file of ECO 550 Assignment 2 Operations Decision consists of: 1. Briefly describe the details of the fictitious business that you created for this assignment. 2. Assess the current environmental scan factor. Determine the factors that will have the greatest impact on plant operations and management’s decision to continue or discontinue operations. 3. Evaluate the financial performance of the company using the information provided in the scenario. Consider all the drivers of performance, such as company profit or loss for both the short term and long term. Be sure to show the calculations that helped you reach your conclusions. 4. Recommend how the company can improve its profitability. Then develop a brief plan to implement the recommendations. 5. Assess the circumstances in which the company should discontinue operations. Provide a rationale with your response. Economics General Economics Assignment 2 Operations Decision Assume you have been hired as a managing consultant by a company to offer some advice that will help it make a decision as to whether it should shut down completely or continue its operations. It currently uses 100 workers to produce 6,000 units of output per month (working 20 days / month). The daily wage (per worker) is $70, and the price of the firms output is $32. The cost of other variable inputs is $2,000 per day. You are told that the firms fixed cost is â€Å"high enough† so that the firms total costs exceed its total revenue. The marginal cost of the last unit is $30. (Ch 7 8 to solve)  This assignment allows you to determine the specific details about this fictitious company in order to conduct an environmental scan of this company.   Write a three to four (4-5) page paper in which you: Briefly describe the details of the fictitious business that you created for this assig Follow the link to get tutorial https://bitly.com/12AXeqz When your classes begin, you have to get acquainted with your instructors. Make sure that you are aware of their office locations, hours of availability and how else to contact them. You must develop good relationships with your professors so that you will feel comfortable talking with them if you need help or an exception on a due date. Economics General Economics Assignment 2 Operations Decision Assume you have been hired as a managing consultant by a company to offer some advice that will help it make a decision as to whether it should shut down completely or continue its operations. It currently uses 100 workers to produce 6,000 units of output per month (working 20 days / month). The daily wage (per worker) is $70, and the price of the firms output is $32. The cost of other variable inputs is $2,000 per day. You are told that the firms fixed cost is â€Å"high enough† so that the firms total costs exceed its total revenue. The marginal cost of the last unit is $30. (Ch 7 8 to solve)  This assignment allows you to determine the specific details about this fictitious company in order to conduct an environmental scan of this company.   Write a three to four (4-5) page paper in which you: Briefly describe the details of the fictitious business that you created for this assignment. Assess the current environmental scan factors that are relevant to the decision making process. Determine the factors that will have the greatest impact on plant operations and management’s decision to continue or discontinue operations. Provide a rationale for your  determination. Evaluate the financial performance of the company using the information provided in the scenario. Consider all the key drivers of performance, such as company profit or loss for both the short term and long term and how each factor influences managerial decisions. Be sure to show the calculations that helped you reach your conclusions. Recommend how the company can improve its profitability to deliver more value to its stakeholders. Then, develop a brief plan to implement the recommendations. Assess the circumstances in which the company should discontinue operations and how management should react when c onfronted with these circumstances. Provide a rationale with your response.

Discuss The Contention That Conflict And Dispute Are Inevitable

Discuss The Contention That Conflict And Dispute Are Inevitable INTRODUCTION Conflicts as well as Dispute are for sure inevitable in most of the commercial projects whether big or small. To be precise, Conflict and Dispute is always there, not only in commercial projects but are a part of our daily life. There is always a conflict going on; on as big as on an international level like ongoing dispute between Israel and Palestine to small issues like a husband and wife having a confrontation as where to go out for dinner. Conflict in simple words can be defined as a disagreement over a situation between two or more parties/individuals where they have there own vested interests. Conflict is short termed and is easy to resolve, while on the other hand, dispute is when it becomes deep-rooted and none of the parties seems to be able to reach an agreement. Conflict can be resolved easily while on the other hand there is a need for a third party intervention to resolve a dispute, which itself is time-consuming, expensive and unpleasant. In other words, we can say that conflict can be managed, but to an extent of preventing it. If not, it leads to dispute. CLASSIFICATION OF CONFLICT Conflict can further be classified as Functional and Dysfunctional, depending on the outcome. Earlier, scholars believed that conflict is a bad thing and should be avoided at all costs, but this was contradicted by Mary Parker Follett (1925), who coined the idea that effective conflict management ought not to conceive conflict as a wasteful outbreak of incompatibilities, but a normal process whereby socially valuable differences register themselves for the enrichment for all concerned. Functional Conflict: It works towards the goal of a project. Mary Parker Follett (1925) called it Constructive Conflict, which increases the information and ideas, encourage innovative thinking, unshackles different point of views and reduces stagnation at any stage of the project. Dysfunctional Conflict: It is destructive in nature and blocks the project from reaching the goal. It brings tension, anxiety and stress for everyone involved. It drives out low conflict tolerant people form the project and reduces the trust for everyone involved, resulting in poor decision making arising due to withheld or distorted information and diversion of resources on the conflict rather than the project. Conflict, in general, can be dealt with by following three methods: Lose-Lose method In this, each side gives up some of its interests. This is done by Avoidance by staying away from the problem or withdrawing but it is not a permanent solution. The other option is Compromise which is done by bargaining and negotiating, in which each side looses something. Win-Lose method Also known as domination, in which there is a victory of one side over other and is done by Dominance where one party overwhelms the other party. Authoritative Command is another aspect where the person with authority rules in favor of one party. Win Win Method: Also known as Integration where each side refocuses there efforts so that neither side loses anything and in fact gains. This is done by finding the root causes of the problem, due to which conflict has arisen and then try to meet the interests of all the parties which in the end leaves everyone happy. TYPES AND LEVELS OF CONFLICT Intra-organization Conflict: As the name suggests, conflicts that occur within an organization, at the interfaces of organizational functions. It can occur along the vertical and horizontal hierarchy of the organizations i.e. between the managers and subordinates or between different departments and workgroups. Intra-group Conflict: It is between the members of a group, and is usually due to ways of doing the tasks or achieving goals. Inter-personal Conflict: It is between two or more people due to differences in opinions and views. This may also be due to differences in orientation to work and time in different parts of an organization. Intra-personal Conflict: It is more of a psychological issue. It occurs within an individual, when a person feels threatened to ones values, has a feeling of unfair treatment. Inter-organizational Conflict: It is between two or more organizations, when they are working together, especially on a project. It is not related to competition. Typical example can be that of a conflict between a supplier and distributor. CONFLICT AND DISPUTES ARE INEVITABLE Conflict and Disputes as mentioned are an unavoidable part of any commercial project by the virtue of the nature of the project. Any commercial project involves a variety of transactions as well as relationships on a local, national as well as international level. Due to the complexity of a commercial project involving client, consultant, contractors, subcontractors and suppliers it becomes inevitable. There can be a number of issues for ambiguity between different parties like project delays, change in scope of work, payment issues, design issues, change in specifications, administrative problems, personal damages, inflation etc to name a few. Managers have to build up, nurture and maintain a network of relationships to make there projects a success. Project Delays: Time management is very crucial for any commercial project. All the activities in a project are lined up one after another and are interlinked. Any kind of delay in this causes the whole project to be delayed, affecting the cash-flow as well as ruining the relationship of all the involved. In many cases financial losses are also incurred by those involved due to delay caused by one of the involved. For example, project handing over got delayed due to delay caused by one sub contractor, and for which the main contractor gets penalized. This penalty he will try to distribute evenly between all his sub contractors, which in turn will not be accepted by those who have finished there scope of work on time, hence leading to conflict. Change in Scope/Specifications: Once everything had been finalized, any change in the scope of work or change in specifications can have a direct impact on the financial as well as the lead time of the project, which can result in the conflict between the parties involved. For example for a project, contractor has already procured some material, or has outsourced a particular job, but when asked to incorporate those changes by the client/consultant, he suffers a financial loss or he has to change the supplier with whom he has placed the order to meet the required specifications. Payments: Conflict can arise due to delay in payments either by one of the parties involved in the project, due to financial crunch or because there has been some delay or there is some defective performance in terms of quality by the other. Whatever the case maybe, it disrupts the cash-flow whole project, affecting parties involved e.g. If a contractor doesnt pays to a sub-contractor, he in turn cannot make the payments to his suppliers as well as employees and defaults, which directly affects the progress of the project leading to conflict between the sub-contractor and the contractor. Administrative Problems: It is another issue for conflict arising due to mismanagement or lack of coordination between different agencies involved, which lead to project delays, cost over-run which in turn results in loss for the project. For example, in a project, scope of work of two sub-contractors is interdependent. If there is no coordination between them, it will result in unnecessary delay for the project. Conclusion: The above mentioned are a few aspects of conflict which are common in any commercial project, whether its a construction, development or an IT project. From here we can infer that conflict is a set of inter-related elements namely: parties, issues, dynamics and context. Since it is very difficult in any commercial project, involving large number of players, to maintain a balance between all these elements, conflict becomes inevitable. Conflict if taken in a positive note, and if resolved appropriately, can leads towards betterment and successful delivery of a project. If not they lead towards dispute which itself is unpleasant, diverts valuable resources from the overall aim, is time consuming, costly and destroys the relationship between those involved which may have taken years to develop. Dispute at all cost should be avoided and should be resolved still when its at a level of conflict. DISPUTE RESOLUTION TECHNIQUES IN A COMMERCIAL CONTRACT In any commercial project, there is always discrepancy/disagreement regarding the scope of work, deadlines, etc which leads to conflicts and when they get out of hand, leads to Dispute. Disputes in general, in a commercial contract are addressed to by the following three methods: Negotiation Mediation Arbitration Negotiation is a tool by which we deal with our differences. These differences may be over the price of everyday grocery, or an automobile or a labor contract or maybe an alliance between the two companies. In general as per the academicians and theorists, there are two types of negotiation theories namely Positional Negotiation and Principled Negotiation. While in positional negotiation, negotiation is done in such a way that the other party looses its faith in its own case and submits to the first demands of the first party, in Principled negotiation, a softer approach is taken to reach a solution. It is based on the following principles: Separate people from Problem, Focus on interests, not positions and Invent options for Mutual Gains. Mediation on the other hand gets the involvement of a third party (neutral) to resolve the outstanding issues and helps them to reach an agreement. Unlike negotiation, it is somewhat semi-formal, with the outcome may or may not be binding to the parties, as per the agreement. In case of Arbitration, it is a formal, private form of an Alternate Dispute Resolution. Here the disputed parties refer to one or more persons (arbitrator or an arbitrator tribunal), who in turn reviews the facts and gives the decision which is legally binding on both the parties. The major difference between Mediation and Arbitration is that mediator always tries to reach a compromise while an arbitrator gives decision which is lawfully binding to both the parties. While Negotiation is very common and is used frequently as compared to Mediation and Arbitration, Mediation is the fastest means to as compared to the other two options. The cost incurred is solving the dispute is highest in Arbitration but depends on number of factors, but still, as compared to Mediation and Negotiation. While Arbitration is recognized by common law and the decision made by an arbitrator will uphold in court of law, this is not true in case of Mediation and Negotiation, but depends on the mutual agreement of the disputing parties. However, if agreed beforehand, the agreement reached via Mediation can also be binding for all the parties involved. Apart from these, Litigation is another dispute resolving technique, to which the disputing parties can resort to. This is a formal process in which the case of the disputing parties is taken to the court and the proceedings are held in public. Compared to Negotiation, Mediation and Arbitration, Litigation is a Slow, time consuming and a very expensive process, where the trials are held in public and there is no scope for confidentiality. THE POTENTIAL USE OF PRINCIPLED NEGOTIATION IN THE INDIAN CONSTRUCTION INDUSTRY Negotiation is a tool used by means of a dialogue between the two or more parties to resolve issues, bargain or to satisfy ones vested interests which can be broadly classified into needs, aspirations, fears and desires. Negotiation is classified into two types: Positional Negotiation Principled Negotiation Principled Negotiation is a relatively new phenomenon, which was coined in late 70s by Fisher and Ury. They gave four basic principles for the Principled Negotiation which are as under-. Separate people from the Problem Focus in interests and not problems Invent options for mutual gains Select among options by using objective criteria Charles G. Fields has described Principled Negotiation as a 7 elements framework namely Interests, Options, Legitimacy, Communications, Relationships, Commitments and Alternatives. INDIAN CONSTRUCTION INDUSTRY AND PRINCIPLED NEGOTIATION After agriculture, construction sector is the largest industry in India. India being a developing country and estimated to become the third largest economy by 2025, and with an economic growth rate of almost 7%, there is a huge demand for the infrastructure and construction projects. Every year, Billions of US$ are spent, both by public and private sector on construction and infrastructure protects. As the construction market is growing by leaps and bounds, so as the conflict and dispute, which then go to the court of law (litigation) to be resolved. The judicial framework of India moves at a very slow pace and is very expensive, and hence there is a need for an alternative. Principled Negotiation, on the other hand is much less time consuming and expensive as compared to litigation and also the relationships between the parties are also not destroyed and consequently the disputing parties reach to a satisfactory agreement. Due to this, not only Principle Negotiation technique but Alternate Dispute Resolution Techniques have a good potential in India. REFERENCES AND BIBLIOGRAPHY: Conflict [online], available: http://webhome.idirect.com/~kehamilt/ipsyconf.html [accessed 10 September 2009] Gray, C. and Larson, E (2008) Project Management: The Managerial Process, 4th ed., Boston: McGraw-Hill. Fisher, R., Ury, W. and Patton, B. (1991) Getting to Yes: Negotiating an Agreement without giving in, Second Edition, Century Business, London. Fenn, P and Gameson, R (Eds) (1992), Construction Conflict: Management and Resolutions, Chapman Hall, London Trust and conflict within virtual inter-organizational alliances: a framework for facilitating knowledge sharing [online], available: http://www.sciencedirect.com/science?_ob=ArticleURL_udi=B6V8S-4CDJKMV-2_user=121749_rdoc=1_fmt=_orig=search_sort=d_docanchor=view=c_searchStrId=1111593104_rerunOrigin=google_acct=C000024058_version=1_urlVersion=0_userid=121749md5=5bf1d2dde69eccc5b0f0becb1595c3f9 [accessed 12 September 2009] Rahim, M. Afzalur , Toward a Theory of Managing Organizational Conflict. International Journal of Conflict Management, Vol. 13, No. 3, 2002. [online] Available: http://ssrn.com/abstract=437684 [accessed 12 November 2009] Fernandez Jimenez de Cisneros, Inmaculada, Dorado, Miguel à ., Martinez, Ines, Medina, Francisco J. and Munduate Jaca, Lourdes, Types of Conflict and Personal and Organizational Consequences. IACM 15th Annual Conference. [online] Available: http://ssrn.com/abstract=305068 or doi:10.2139/ssrn.305068 [accessed 12 November 2009]

Walt Disney :: essays research papers

Walt Disney   Ã‚  Ã‚  Ã‚  Ã‚  Walt Disney was one of the famous motion-picture producers in history. He first became known in the 1920's and 1930's for creating such cartoon film characters as Mickey Mouse and Donald Duck. He later produced feature length cartoon films, movies about wild animals in their natural surroundings, and films starring human actors. Disney won 32 Academy Awards for his movies and for scientific and technical contributions to filmmaking. He also gained fame for his development of theme parks.   Ã‚  Ã‚  Ã‚  Ã‚  Walter Elias Disney was born on Dec. 5, 1901, in Chicago, Illinois. His family moved to Missouri, and he spent much of his boyhood on a farm near Marceline. At the age of 16, Disney studied art in Chicago. In 1920, he joined the Kansas City Film Ad Company, where he helped make cartoon advertisements to be shown in movie theaters.   Ã‚  Ã‚  Ã‚  Ã‚  In 1923, Disney moved to Los Angeles to become a film producer or director. When he failed to find a job, he returned to producing cartoons. He set up his first studio in the back half of a real estate office. For several years, Disney stuggled to pay his expenses. He gained success in 1928, when he released the first short cartoons that featured Mickey Mouse. Earlier filmmakers had found that animals were easier to animate than people. Mickey Mouse, drawn with a series of circles, proved ideal for animation.   Ã‚  Ã‚  Ã‚  Ã‚  In 1927, sound that had been added to motion pictures, and a process for making movies in color was developed a few years later. Disney and his staff made imaginative use of sound and color. Disney himself provided Mickey Mouse's voice for Steamboat Willie (1928), the first cartoon to use synchronized sound. His cartoon Flowers and Trees (1932) was the first cartoon in full Technicolor.   Ã‚  Ã‚  Ã‚  Ã‚  From 1929 to 1939, Disney produced a cartoon series called Silly Symphonies, which played in theaters along with other animated films featuring Mickey Mouse and other characters, like Donald Duck, Goofy, and Pluto. After 1924, Disney actually did more of the drawing necessary for his animated films. His genius lay in creating, organizing, and directing the films.   Ã‚  Ã‚  Ã‚  Ã‚  In 1937, Disney issued the first full-length animated feature film to be produced by a studio, Snow White and the Seven Dwarfs. It became one of the most popular movies in history. Disney's later full-length animated films included Pinocchio (1940), Fantasia (1940), Dumbo (1941), Bambi (1942), Cinderella (1950), Alice in Wonderland (1951), Peter Pan (1953), Lady and the Tramp (1955), Sleeping Beauty (1959), 101 Dalmations (1961), and the Jungle Book (released in 1967, after his death). In 1950, Disney released Treasure Island, his first full-length movie to use only human actors.

Douglas McGregor’s Theory X and Theory Y Essay -- Business Management

Douglas McGregor’s Theory X and Theory Y Biography of Douglas McGregor Douglas McGregor was born on 1906 in Detroit, America. In 1895, it was here that his grandfather, Thomas McGregor started his business and given its name as, McGregor Institute. The business provides assistance to Great Lakes sailors and other transient labour. The Institute provided shelter, warmth and food to approximately 100 men every year. When Thomas McGregor passed away, his son Murray McGregor (Douglas’s father) continued to manage the business. During high school, Douglas McGregor worked as a night clerk and played the piano and organ at the chapel services. At work, he became familiar with the employees and their problems. In 1936, McGregor Institute came to an end and it was sold for $100,000 to the Goodwill Industries. After high school, McGregor went to Oberlin College and then attended to Wayne University, where he had graduated in 1932. While at college, he was married and left his college work for about five years to save enough money to start a family. McGregor began as a gasoline station attendant in Buffalo and quickly progressed to district manager of stations in the Detroit region. In 1935, he received a PhD degree from Harvard University in Experimental Psychology. McGregor was a brilliant student at Harvard that; he achieved an A grade in every course. After his graduation from Harvard University, he became a Professor of Psychology and taught there f...

Herb Brooks: Charismatic Motivation in Coaching Essay -- essays resear

Herb Brooks: Charismatic Motivation in Coaching In the following essay, I will argue that Herbert â€Å"Herb† Brooks was a charismatic leader due to his powerful motivation and his high expectations. He expected great things from the players he coached, but mostly, he expected them to think of the team and not themselves. He motivated with a powerful punch, mostly through fear, but was able to unite his teams and eventually the country. Herb Brooks was born on August 5, 1937 in St. Paul Minnesota (Herb Brooks). Growing up in Minnesota, he became attached to the sport of ice hockey. He spent years practicing and playing this sport, and in 1955, he led his high school team to the state championship. After three years of college at the University of Minnesota, he joined the 1960 Olympic hockey team, but was cut from the team just before the Olympic games. He played for the United States in the next two Olympic games, and in 1970 he picked up his coaching career at the University of Minnesota. In his six year’s of coaching at the university, he led the team to three national championships (Herb Brooks). In 1980, his United States Olympic hockey team, consisting of all college students, achieved one of the greatest spectacles in sports history: â€Å"The miracle on ice.† His team beat the Soviets in a white-knuckle, heart pounding game with a score of four to three. The Soviet’s were a well trai ned, terrifying team that were considered to be the greatest hockey team that has ever taken the ice. After leading his team to this miraculous victory, he continued his coaching career up until his tragic death in 2003. His high expectations for his team and his fearful, powerful motivational techniques led him down a path of greatness that helped him become an inspiration to all. Brooks' 1980 Olympic hockey team consisted of college students whose average age was 22 years, and was full of rivalry because of players being from different universities. This young team was being matched against some opponents who had played and practiced together year-round, for several years. The Soviets had beaten a team of National Hockey League all-stars the year before, and they triumphed over this young U.S. team at an exhibition game in New York a week before the Olympiad (Herb Brooks). Herb did not ... ...out the best in every player that played for him. Although he seemed harsh at first, the team members bought into his methods of motivation, and became united as a team. Herb communicated to them his goals and aspirations, and the team was able to set its sights on the future. He had many dreams, and once said, according to the ESPN website, "You know, Willie Wonka said it best: We are the makers of dreams, the dreamers of dreams. We should be dreaming. We grew up as kids having dreams, but now we're too sophisticated as adults, as a nation. We stopped dreaming. We should always have dreams. I’m a dreamer.† His dreams bringing out the best in every player became reality, and it not only united his team, but it united the country. Herb Brooks was a great inspiration to his many team members throughout the years, and now he is remembered as a powerful motivator and an inspiration to the nation as a strong charismatic leader. Works Cited Herb Brooks. Retrieved April 14, 2005 from the world wide web: http://galenet.galegroup.com. Coach Known Best for 1980 Hockey Gold. (2003, August). The Associated Press. Retrieved April 14, 2005 from the World Wide Web: http://www.espn.com.

It is inhuman and offers no solution to unwanted pregnancies

Abortion is the act by which a pregnancy is prematurely terminated to result in the death of a foetus or unborn child. The life of the developing child is destroyed and the child therefore loses the chance of being born into this world.Various methods are used to perform or carry out an abortion such as use of medicine, surgery or any other methods of extraction some of which are very crude. Abortion dates way back into history and has been a social evil that society has had to put up with for a long time. In traditional society such methods as botanical products, exerting pressure on the abdomen and use of sharpened tools were used to perform abortion.With advanced civilization   these methods have changed to result to more modern methods that are medically safe. Crude methods however cannot be ruled as many women will tend to maintain secrecy about the whole issue or they may not afford to visit clinics (Riddle ,John M.).Several reasons lead to abortion but the most common one is unwanted pregnancies. Such pregnancies result from failed methods of contraception, rape, incest or even careless or unprotected sex.Special cases such as complications arising from a pregnancy also result in abortion where the urgency to save the life of the mother becomes inevitable. In the course of medical examination doctors may also detect complications in the development of a foetus and decide to terminate a pregnancy depending on the degree of destruction to the foetus.Pro-abortion activists argue that there is no need of bringing an unwanted child into this world. Children resulting from rape and incest for example come at a time when the mother is least ready for the responsibility. They are not conceived through a relationship and in the event of conception through rape the fathers may not even be known.Many people find it unhealthy to bring such children into the world because of the injustices they are likely to face in society.   Of all the injustices faced by child ren in the world however,   abortion is the worst of them all as it denies an unborn child the most basic human right; to be born and be raised in this world.Denying a child the right to live means that such a child loses the chance to be anybody in society and society has therefore been denied the services of great men and women through abortion (Edward Richards P, Katharine Rathbun C.).Despite rigorous campaigns against abortion, the evil has been on the increase in present day society.. This is due to advance in the field of medicine that has made abortion safer thus reducing the risk of death during the process.As a result, it has become an easy way out for many women especially young adults who engage in careless sex due to the promiscuous nature of society today.   But how safe is safe remains a topic of discussion regarding abortion.Though abortions carried out medically may be safe, the side effects may be far reaching and may not be realised immediately. The reproductiv e system of a woman for example may be destroyed and she may not be able to have children in future.This is traumatic as the woman is unable to overcome the guilt of contributing to her barrenness and the lack of children may lead to the break up of marriage where the woman is in such a relationship. The frustrations and psychological torment may be too much for the woman to bear (Edward R. P, Katharine R.C.).Due to increased number of abortions, a lot of people have come up with the argument that it should be legalised. They argue that legalising abortion will help to reduce abortion related deaths that result from crude methods because clinically induced abortion would now be accessible to those who wish to have it.

Marketing Synopsis

After the Initial success of the casual shoes, GOES expanded its market towards the apparel and the sports shoe market as well, thereby demonstrating the power of Innovation. Since then, GOES had carved out a niche for itself through distinctive innovation. It has been adopting strategies to ensure that it could successfully renew its technology, products and process, and maintain long term competitiveness. Key Issues and Fact Finding: * According to us, first issue was, Polecat had no prior knowledge in the field of engineering and shoe industry. The research process was exhaustive.After insulting various publications and encyclopedias he recognized that a watertight breathing membrane worn by NASA astronauts can act as a prototype for his shoes. * After patenting the new technology, second issue was that none of any shoe leading companies in Italy showed interests in his product. This led him to manufacture the shoes all by himself. * Third Issue was that after diversifying Its pro duct portfolio and expanding Internationally, GOES could not enter sports shoe market as it had intense competition and it required a very different technology.Polecat felt that every sector requires a different mind-set, but in response to nonuser requests, Golf Shoe range was launched in 2009. * The last and the major key Issue was that shoe market was highly competitive and to maintain Its position, only innovation could not help. The shoes must be stylish and trendy enough to match the style offered by others. Thus GOES had to constantly work on product differentiation while maintaining its quality and costs. Key Learning: * The very first thing this case teaches us is that â€Å"Necessity is the mother of invention†.We must be constantly aware of our surroundings. One should have zeal and enough confidence on oneself to convert the opportunity in potential offering. Polecat realized the necessity of the shoes that breathes and created a new market altogether. * Take smal l steps and have full faith in your potential. Polecat initially 1 OFF small. This gave him an opportunity to test the response of the customers in limited period of time. After getting satisfactory response, he then switched over to men and women wear and expanded the market gradually. * â€Å"Think big†.Initially he started locally and then expanded its target market by entering in apparels and sport shoes. The company then, internationally diversified its product portfolio. Polecat realized his true potential and knew to what extent he could go. Questions: IQ . What do creativity and innovation Signify and entail? What are the key types of innovation? SQ. Analyses Goose's innovative strategy in detail. What are features of this strategy that have made Goes shoes a success? What factors, other than product innovation, does Goes owe its competitive advantage to?Q. 3. Assess the market environment of the industries Goes operate in. Who are Goose's key competitors? What Strate gies and options are available to Goes for sustaining its position in these industries? ANSI : Creativity: The process of generating ideas and new ways of doing things is called as creativity. This term is more frequently used in arts. It more refers to the thought process. Innovation: The process of generating ideas and filtering them checking the feasibility of the idea and implementing the idea to create value is called innovation.In simple terms it is the process of creating value by generating new ideas or changing existing ideas. Creativity is a part of innovation. Types of Innovation: Product Innovation: It involves the process of creating new products or altering existing product with new technology in order to create value to the customer. Process Innovation: It involves the key changes in the way of doing business. Impact of process innovation would be big. It should be communicated with the end user effectively.Service Innovation: Creating new service applications which e nables the customer much convenience. NAS:2 Innovation strategy for GOES: A good idea, constant collaboration with universities in order to see if idea is feasible and improve it and a patent to protect the innovation. Success Factors: * Company invested heavily in R&D. In 2008 GOES spent SIS$ 20. Million on R&D expenses. * GOES emphasized on the value of the patents. It made development of â€Å"Breathing Technology' its mission and held over 50 patents in this field.These 50 include Rubber soles patent, Leather soles patent, Apparel patent, patents related to processes, equipment and machinery and material. These patents helped in gaining competitive edge. Factors that Gave Competitive advantage: They positioned themselves as one of a kind catering to the entire family. Product categories were based on the target customer Target customer: Male, Female, Pricing: Medium to medium-high price range of market Product Categories: Classic products which were elegant and traditional.Casu al products which were wearable and adaptable. Production: High quality standards, continuously improving flexibility and time to market, Cost leadership. Marketing: They concentrated around the product features I. E. Technology rather than only concentrating in the fashion and style thus making a clear differentiation from other products. They advertised using the images of product and breathable sole technology. Distribution System: Very efficient and adaptable distribution system for each country they operate in based on their structure.

Final Assignment

Additionally, it will show which changes will be made that will have a positive exult to our program not only now, but in the future as well. Readiness of our Leaders There are several leaders in this change the principal, H. O. S. T. Administration Migrant Education, Reading Teacher, several paraprofessionals, and our SST including myself. Together we identify the core elements and negotiate items in our change plan. The main change is to increase the time allotted students to do reading at our program.Program/practices for scale and sustainability Our program has and is having success in empowering students to grow al develop in a safe and caring environment. The area that can be improved the enriching environment, why? First, the program needs to have access computers in the area where HOST is located. Second because the student get computers time only three days out of the week and for 20 minutes a c while at HOST. Third, the students are given 30 minutes, but by the time t' go t o and from the computer lab, which takes them 10 minutes, they only 20 minutes at most.My personal feelings are that our children can benefit from having their own computer lab at HOST or tablets that they can access anytime they are in the aftershock program. Most of the students at our aerogram are of Hispanic decent some of them struggle in reading, comprehension and writing. I can only imagine what can be done to help them in those areas if we had our own computers or tablets. Our student have a 30 minute block in which reading is being implemented already, if v had reading and writing software on tablets Or Computers Our students cal reap the benefits. What is it?Why is it important? In order for our program to continue to empower students to grow and develop in a safe, caring, an educationally enriched environment feel that the students need more reading time. My thoughts are that if the students had tablets in our aftershock program to work with in reading that they would mak e rapid advancement in reading. The stakeholders that will approach are the principal at the school, since she is a person that commends a lot of power In other words when she speaks people listen, plus she knows other people as well that have that type of authority.Identifying the main change will assist us to determine whether or not all elements within this change are crucial. At this point our plan can be tweaked to fit the needs of our studs The need and wiliness of all stakeholders to relocate resources for the Ben f our change plan is amazing. In corporations or companies change is evitable and a must in order to stay in the game. The key to change is to b willing to listen to others opinions. How is it high quality and valued by stakeholders? This change is high quality because of the students that this change target!Most of the students are Engle sis Language Learners and struggle with comprehension. Some of them are behind in their level of reading and writing skills. What results are anticipated? This change will be enriching the students in that they will increase their level of reading, comprehension ND writing skills. The stakeholders will benefit because they will actually s the students progress. Non-negotiable elements of the program/practice There will be items in the change plan that is nonnegotiable in order to keep the integrity of the change.During our planning stages as a group we decided that reading and comprehension were nonnegotiable. These two items are non-negotiable since they are our focal point of interest. Without these two we would not have a need for the change plan. Scale and sustainability scores In order to define the scale and sustainability score of the change plan we ad to review the Scale and Sustainability scores located within the book â€Å"Leading Change Step-By-Step† by Jody Spiro. These results will let us know to what extent certain features have been merged into our program (Spiro, 201 1).Our results sho w that we have an all-inclusive plan, but not all stakeholders have bought into it yet. What this says about us is that we are good at working together and coming up with a plan. However, this does not mean that everyone agrees with it. There is still some resistance to the actual plan change. This of course is expected, since change is never easy, nonetheless a good way to get individuals on board is by communicating and educating them. Education & Communication: One of the best ways to overcome resistance to change is to educate people about the change effort beforehand.Being upfront with education and communication lets everyone have knowledge about the changes. â€Å"People tend to see things that are happening now as more urgent than those that will happen in the future. † (Weber, 2006). Sometimes individuals are afraid of something they do not understand, however once they learn how this change is to come or will be made they are not as afraid. It is only then that they will start asking questions once they are informed. This however is not a guarantee that they will accept the change right away, but now they are more ready to listen to what one has to say.The development of scale and sustainability strategies for the change strategy Creating an environment where there is open communication and providing them an outlet to speak about their concerns will minimize a lot of the resistance. Providing the team with a consistent and clear message will minimize resistance. If change my views or do not sound confident in my change plans, the message will be inconsistent. On the other hand, if I am consistent and clear; offering a clear vision and specific goals to achieve, the team will be focused and know what is expected of them.I will also make sure the â€Å"messages are communicated through the participants' ears† (Spiro, 201 1). Communication is a key element, for this element we scored a five. However, this needs to be on a continual basis i n order for the group to be informed throughout the school year. Communication is not something that happens last minute; it is something that is practice throughout with co- workers. In conclusion ‘Veneered you introduce change, you are sure to encounter barriers† (Drexel & Muskier, 2012). The best change leaders; will have a plan B for when things go wrong.Knowing your group, making sure you communicate with them and realizing you cannot make change happen alone will help your change effort become successful. Communication must be clear and consistent while your plan needs to have important feasible goals. Another area to be aware of is that the plan change is not written on stone and that there might be changes that will take place throughout the planning stages. What one might come up with at the end as a leader for hanger might be totally different than what one started with.

Alzheimer’s Disease Amyloid Precursor Protein Gene

Alzheimer’s disease, AD, is a distressing condition that involves the decline in cognition of the mind which results to psychotic disorder, and affective and behavioral disturbances (Bloom 9). It is a progressive central nervous system disorder and the main cause of dementia (Stavljenic-Rukavina 1). Alois Alzheimer in 1907 reported the case of a 51-year old Frankfurt woman who died in dementia (Bloom 9). He described the neuropathological condition of the woman with neurofibrillary tangles or NFTs and amyloid plaques or NPs (Bloom10). NPs are extracellular beta-amyloid peptide or A?Spherical deposits closely related to dendrites, reactive astrocytes, dystrophic axons, and activated microglia (Felician and Sandson 19). Thus, for several decades, collaborative efforts of experts from different scientific and medicinal endeavors were devoted for the neurological and pathophysiological characterization of this disease (Bloom 9). As such, the roles of four specified genes, as well as the mechanism of oxidative stress, tau, inflammation, hormonal changes, and inflammation on the AD’s neurodegeneration have been the central theme of scientific studies conducted on this disease (Felician and Sandson 19).As experts continuously gained insights on the mechanisms of neurodegeneration, pharmacological strategies are concurrently devised for the development of appropriate drug treatment and interventions (Felician and Sandson 19). Molecular Mechanism Early and late onset ADs are types of familial AD which are genetically heterogeneous. Familial AD is accounted for 10% of AD cases from 30-60 year old patients and ascribed to three types of genes which included APP, presenilin-1 or PSEN1 and presenilin-2 or PSEN2 (Stavljenic-Rukavina, 1).Nonetheless, the mutations in these genes also cause A? -level increase; A? is generated by proteolytic APP fragment that was also observed in the brains of AD patients (Stavljenic-Rukavina, 2). However, not all AD cases can be attributed to the three identified genes. Genes are then the most important determinant of AD development (Stavljenic-Rukavina, 2). On the other hand, there is a great chance for children with parents having history of familial AD to inherit the genetic traits and develop either early-onset or late-onset AD (Jayadev et.al. 375). As well, AD development threat in the offspring is directly related to age; the tendency of AD occurrence among children of parents with historical AD background increases as the children gain progress in their growth and development (Jayadev et. al. 375). The pathogenesis of Alzheimer’s disease, on cellular level, has been consistently observed. The pyramidal neurons are the type of cortical cells that are fundamentally deteriorated in AD pathogenesis resulting to the spread of NPs and NFTs in cortex areas (Felician and Sandson 20).Both NPs and NFTs are normally found in brain areas in the aging process but their concentrations and densities are pecu liar in the case of AD (Felician and Sandson 20). Originally, NPs are found at the amygdala and concentrated in parietal association and order temporal cortex parts (Felician and Sandson 20). In the maturity of AD, NPs can also be observed in hippocampus, in other structures of mesial temporolimbic brain, and even in cortical and meningeal blood vessels (Felician and Sandson 20).Luckily, the areas for sensorimotor and visual are remained unaffected. Meanwhile, in the early stage of AD, NFTs can be found hippocampus, amygdala, and in entorhinal cortex, the association cortex has abundance of NFTs (Felician and Sandson 20). However, NFTs are not exclusively for the cases of AD, these are also detected in the several cerebral troubles like in dementia pugilistica, postencephalitic parkinsonism, and subacute sclerosing panencephalitis (Felician and Sandson 20). The formation of NPs is attributed to the A ? peptide deposition; A ?peptide types that only differ in C-terminal are common in cerebrovascular and extracellular plaques (Felician and Sandson 19). A ? peptide, made up of 39-43 amino acids, is normally generated from APP or amyloid precursor protein. In addition, the series of hydrophobic C-terminal is crucial in its solubility and amyloid formation rate (Felician and Sandson 19). As such, A ? with 40 amino acids, A ? 40, as well as A? peptide with 42 and 43 amino acids or A? 42 and A ? 43 respectively (Felician and Sandson 19). However, in vitro, the variants of A?42 and A? 43 can easily form insoluble fibrils as compared with the A? 40 variant (Felician and Sandson 19). Furthermore, the incubation of these A? variants can immediately lead to coalescence implying the possible amyloid plaque deposition through these components. In line with this, diffuse plaques have nonfibrillary and A? soluble constituents denoting the senile plaques’ early stage (Felician and Sandson 19). Likewise, diffuse plaques have A? deposits in the absence of neuritic degener ation (Felician and Sandson 19).On the other hand, neurofibrillary tangles, comprised of abnormal bundles of intraneuronal filaments, are made up of tau microtubule-associated protein with high degree of phosphorylation (Felician and Sandson 19). The degree of phosphorylation is largely dependent on the enzymatic activities of kinases that are not yet fully understood (Felician and Sandson 19). Nevertheless, the intraneuronal abnormal filaments arrange themselves in either parallel or helical bundles in perikaryotic cytoplasm that make them in contact with the dentritic processes (Felician and Sandson 19).The amyloid precursor protein, a membrane glycoprotein, is consisted of 28 A? extracellular residues and 12 to 15 putative transmembrane residues (Felician and Sandson 20). It also occurs as 695, 751, and 770-amino acid isoform. While the 695-amino acid isoform occurs mainly in neurons, 770 and 751-amino acid forms are seen on both non-neural and neural cells along with protease in hibitor domains (Felician and Sandson 20). APPs are carried into the cell membrane by secretory vesicles and may undergo proteolytic bond breakage through the action of ?-secretase (Felician and Sandson 20). Consequently, this cleavage generates ? -APP, a soluble ectodomain and the precursor for A? peptide production through cleavage in A? domain. As the generation of soluble APP is, in vitro, ascribed with the activity of protein kinase C, uncleaved APP is inferred to take the proteolytic pathway (Felician and Sandson 20). On the other hand, APP intracerllular recycling and management are done through endocytotic or endosome-lysosome means. The endocytotic route causes proteolytic cleavages by means of ?– and ? -secratases leading to the synthesis of A? (Felician and Sandson 20). Moreover, A? production is enhanced by intracellular calcium concentration which denoted the significance of calcium-rich proteases in A? production (Felician and Sandson 20). In vivo, APP cleavage occurs at N-terminus at the A? -region through the action of ? -secretase and at the C-terminus by means of ? -secretase activity (Mohan 1). Also, APP can take a pathway facilitated by ? -secretase at the A? -peptide domain producing soluble ? -APP (Mohan 1).Ezymes can also possibly attack APP without A? -peptide generation (Stavljenic-Rukavina, 1). Since the putative ? -secretase, under the control of kinase C, regulates the generation of soluble APP, any agents that supports this metabolism may hinder the A? production (Felician and Sandson 21). As well, A? deposition may also be lessened by drugs which inhibit APP cleavage into ? – and ? -secratases (Felician and Sandson 21). Nonetheless, agents that can impede A? coalescence would decrease its neurotoxicity effects (Felician and Sandson 21).After the formation of amyloid plaques, neurofibrillary tangles and inflammation dictates the death of neurons (Stavljenic-Rukavina 1). In relation to this, microglia and astrocytes ce lls of the brain are heavily affected by inflammatory process (Stavljenic-Rukavina 1). In AD patients, astrocytes are enlarged and produce prostaglandin which in turn sends signal to activate the inflammation mediated by arachidonic acid (Stavljenic-Rukavina, 1). On the other hand, microglia generates free radicals which cause neurons’ death (Stavljenic-Rukavina 1).Meanwhile, cell nutrients as well as its regulation components are transported through the microtubules in which structural properties are mainly dependent on tau protein (Stavljenic-Rukavina 1). In AD condition, the tau lessens its capability to bind with microtubules and binds with other tau protein resulting to knots of helical filaments called as neurofibrillary tangles (Stavljenic-Rukavina 1). APP Duplication is Sufficient to Cause Early Onset Alzheimer’s Dementia with Cerebral Amyloid Angiopathy Studies showed that A? encoding through APP gene expression leads to the development of Alzheimer-type demen tia (Sleegers et.al. 2977). APP genetic expression results to elevated levels of A? 42, a 42-amino acid product of the proteolytic process (Sleegers et. al. 2977). Aside from the cleavage of APP into alpha, beta, and gamma secretases, high APP genetic expression results to elevated levels of A? 42 and A? deposition (Sleegers et. al. 2977). Meanwhile, it has been long known that APP level triplication in Down’s syndrome patients results to the development of Alzheimer type dementia at early stage; the APP excessive expression leads to neurodegeneration and A? deposition (Sleegers et. al.2977). In relation to this, it was reported that families with cerebral amyloid angiopathy and early onset Alzheimer type dementia had APP genomic duplications which implied that APP over-expression, without full trisomy 21, has triggered the Alzheimer-type dementia (Sleegers et. al. 2977). In addition, Alzheimer-type dementia patients have elevated APP mRNA levels in their brains (Sleegers et. al. 2977). Further, the variation on the transcription of APP gene due to genetic factors was believed as the underpinning factor in the pathogenesis of the disease (Sleegers et.al. 2978). In fact, three APP mutations were observed on Alzheimer-type early-onset dementia patients. These mutations, as seen in vitro by means of trisomy 21, caused a two-fold elevation of in APP transcriptions (Sleegers et. al. 2978). With the aforementioned evidences on APP elevation through APP genomic mutations or duplications which resulted to the development of early onset AD, it could logically infer that A? has a crucial role in its aetiology (Sleegers et.al. 2978). Hence, for the evaluation of APP locus duplication on Alzheimer-type dementia cases, Sleegers et. al. conducted a study on Dutch population with early onset Alzheimer-type dementia patients. Material and Methods In the approval of the University of Antwerp medical ethical committee, the respondents of this research were recruited form an epidemiological study on early onset AD in several provinces of The Netherlands and in Rotterdam (Sleegers et. al. 2978).Patients with early-onset dementia diagnosis were enlisted based on the recommendation of medical experts and healthcare providers. As such, the assessment of the patients’ conditions was done in accordance with the standards of the Stroke-Alzheimer’s Disease and Related Disorders Association, and the National Institute of Neurological and Communicative Disorders (Sleegers et. al. 2978). Medical records of the patients and their respective relative with similar trait inheritance were made available for an in-depth examination.Meanwhile, for the assessment of genetic inheritance, 111 patients with ages 33 to 65 years old of which had 75 respondents with familial background of either late or early-onset of dementia and 10 of which have autosomal dominant inheritance history for several generations of their respective clans were studied (Sleegers et . al. 2978). The genomic DNA or gDNA was derived from lymphocytes and alleles of APP were measured by means of real-time polymerase chain reaction, PCR (Sleegers et. al. 2978).Also, the PrimerExpress software was utilized for the design of ? 2-microglubulin or hB2M, exon 5, 11, and 18, ubiquitin C or hUBC, ATP5J, APP, and GABPA (Sleegers et. al. 2978). As the APP alleles were normalized for hB2M and hUBC, 20 nanograms of genomic DNA were combined with the PCR and 400 nanomoles of the respective primers (Sleegers et. al. 2978). Finally, the duplication of the samples was done by means of dosage quotients or DQs calculation through six normal individuals and dementia patients.Patients with trisonomy 21 were also included as controls (Sleegers et. al. 2978). Fluorescence in situ hybridization, FISH, was utilized to determine APP genomic duplication (Sleegers et. al. 2978). FISH was performed on both interphase nuclei and metaphase chromosomes while the Epstein-Barr virus-transformed pa tients’ lymphoblasts were taken from the metaphase period by means of 0. 1 microgram/milliliter colcemid treatment and incubated, at 37 °C for 25 minutes, in hypotonic solution of 1 molar sodium hydroxide, 30 millimolar glycerol, 0.8 millimolar magnesium chloride, 2 millimolar HEPES, and 1 millimolar calcium chloride (Sleegers et. al. 2978). This suspension then was used for 106 cells per milliliter as the chromosomes’ mechanical stretching was done through cyto-centrifugation. On the other hand, the Multiplex Amplicon Quantification, MAQ, was applied in the detection of APP locus duplication. MAQ was comprised of multiplex PCR amplification of the reference amplicons and targets which were tainted with fluorescent substance (Sleegers et. al. 2978).After MAQ, DNA fragment analysis, and comparison target amplicon DQ between control individuals and the patients were done (Sleegers et. al. 2979). Results and Discussion Real-time PCR APP measurements of 10 probands showe d heterozygous duplication (Sleegers et. al. 2982). Based on the Dutch population sample, APP duplication along with segregation pattern and neuropathology tantamount to autosomal dominant inheritance and AD with excessive CAA were identified with APP duplication in a family (Sleegers et. al. 2982).Specifically, the genomic APP locus duplication were observed in five of the 65 family cases with early onset AD autosomal dominance while APP duplication was detected in a single out of ten family cases early-onset AD autosomal dominance (Sleegers et. al. 2982). Even though these numbers are small, the data generated from this study illuminated the significance of genomic APP locus duplication assessment when simple mutations were excluded in AD known genes (Sleegers et. al. 2982). In the 65 patients with familial AD history, a single genomic duplication was identified (Sleegers et. al. 2982).In addition, the genomic duplications among the Dutch samples have 1. 8% overall frequency and 2 . 7% frequency in AD patients and family (Sleegers et. al. 2982). In contrast, duplication was failed to be detected on 36 patients with irregular early-onset AD which denoted that the duplication of de novo genomic APP is a weak cause of early-onset Alzheimer-type dementia (Sleegers et. al. 2982). Moreover, the duplication observed among the Dutch family samples has only APP which proved that genomic APP duplication, regardless of adjacent genes, has the capacity for AD and CAA mixed phenotype (Sleegers et.al. 2982). As well, duplication size differences signified the non-specific recombination substrate from the genomic attributes of APP locus; APP rather is in increased recombination region as imparted by other factors such as low transcription repeats (Sleegers et. al. 2982). Nevertheless, the mutation that affects APP expression among 4. 5% of the Dutch participants that either genomic APP duplication or APP mutation promoter carrier, are the frequent cause of Alzheimer-type de mentia (Sleegers et. al. 2982). Polymorphism in the Promoter of the Human APP GeneThe cleavage of APP produces A? with associated neurotoxicity; hence, genetic studies postulated that abnormal A? deposition neuropathologic AD conditions (Athan, Lee, Arriaga, Mayeux, and Tyco1793). The abnormal deposition of A? in AD patients has been ascribed to APP gene missence mutations and the proteolytic APP cleavage producing A? 42 which in turn triggers the development of early-onset AD (Athan, Lee, Arriaga, Mayeux, and Tyco1793). The most solid proof for this notion is the case on trisomy 21 wherein the duplication of APP gene results to increased A?peptide level and aggregation of such in the amyloid plaques of the brain (Athan, Lee, Arriaga, Mayeux, and Tyco1793). While the presenilin enyzymes enhance fibrillogenic APP conversion, the APOE or alipolipoprotein-E elevates A? coalescence and deposition (Athan, Lee, Arriaga, Mayeux, and Tyco1793). Since A? production is associated with APP con centration and on other factors in both A? and APP syntheses, it was hypothesized that the expression of APP gene is a determinant of AD development (Athan, Lee, Arriaga, Mayeux, and Tyco1793).Recently, a study reported the weak relation between AD inheritance and microsatellite sequence in the APP first intron and a tetranucleotide non-association with AD (Athan, Lee, Arriaga, Mayeux, and Tyco1794). Hence, to further scrutinize this issue, Athan et. al. anchored their study on APP promoter variant screening in tri-ethnic populations which included white, Caribbean Hispanic, and African-American as they intended to determine APP promoter identities. MethodologyThe respondents in this study were Manhattan residents of Washington Heights with ages of more than 65 years (Athan, Lee, Arriaga, Mayeux, and Tyco1794). Personal interview and medical background check, neuropsychological, physical and neurological examinations were done on the participants. In addition, individuals with quest ionable dementia, Parkinson disease, and other types of dementia were excluded in the study. Consequently, a total of 1,077 participants was successfully enlisted, whereas, 16% of them has family history of stroke (Athan, Lee, Arriaga, Mayeux, and Tyco1794).For genotyping, DNA from 1,013 respondents was taken as the panel of neuropsychologists and physicians established the criteria for the identification of AD patients along with the Clinical Dementia Rating Scale (Athan, Lee, Arriaga, Mayeux, and Tyco1794). The oligonucleotide primers used for APP promoter PCR amplification came from GenBank (Athan, Lee, Arriaga, Mayeux, and Tyco1794). From genomic DNAs and by means of Platinum Taq DNA Polymerase, the fragments were amplified while the product sequence was determined through dye terminators (Athan, Lee, Arriaga, Mayeux, and Tyco1794).Meanwhile, 15 microliter of the PCR products was introduced into WAVE fragment DNA analyzer (Athan, Lee, Arriaga, Mayeux, and Tyco1794). The haplotyp es PCR products were individually cloned through pGL3 vector in between SacI and Bg III sites (Athan, Lee, Arriaga, Mayeux, and Tyco1794). On the other hand, U-87 MG glioma cells were cultured with the solution of Earle’s balanced salt and 2 millimolar L-glutamine with 10% fecal calf serum in EMEM medium (Athan, Lee, Arriaga, Mayeux, and Tyco1794).At 70% confluence, the cells were transferred by means of FuGene 6 reagent and pGL3 vectors were added to transfected DNA to maintain a constant concentration of about 1 microgram per plate of 35 squared millimeter (Athan, Lee, Arriaga, Mayeux, and Tyco1794). While the isotonic solution of phosphate-buffered sodium chloride was used to wash the U-87 cells, the 250 microliter Reporter Lysis Buffer was applied for cell lysis (Athan, Lee, Arriaga, Mayeux, and Tyco1794).After this, the centrifugation of the cell extract was done at 10,000 g for five minutes. From the supernatant, 20-microliter aliquot was taken and combined with 100 mic roliter Luciferase Assay Buffer for luciferase activity measurement (Athan, Lee, Arriaga, Mayeux, and Tyco1794). Then, with 10-20 microliters of the lysate ? -galactosidase assays were performed. This ? -galactosidase measurement was utilized for the normalization of the luciferase data (Athan, Lee, Arriaga, Mayeux, and Tyco1794).Each allele was counted and by sample proportion calculation, the frequencies were computed (Athan, Lee, Arriaga, Mayeux, and Tyco1794). For the ethic group comparison of allele frequency, chi square analysis was applied while logistic regression was utilized for APP promoter and AD polymorphisms odd-ratio calculation (Athan, Lee, Arriaga, Mayeux, and Tyco1794). As well, for each ethnic group, logistic regression was employed as the data were classified with respect to the APOE allele’s occurrence or non-occurrence as education and age discrepancies were adjusted.Finally, Hardy-Weinberg equilibrium was analyzed through chi square analysis while the e thnic comparison of APP promoter and AD polymorphisms odd-ratio calculation as their education, age, and sex were adjusted (Athan, Lee, Arriaga, Mayeux, and Tyco1794). Results and Discussion Two types of APP promoter polymorphisms were detected and identified, with respect to the starting site of the transcription, as G>C at +37 and G>C at -9 variants (Athan, Lee, Arriaga, Mayeux, and Tyco1797).In connection to this, +37C allele was typically observed among 18% African-American respondents while European and Caribbean-Hispanic have 3% and 10% respectively (Athan, Lee, Arriaga, Mayeux, and Tyco1797). Although +37C allele was commonly observed among AD patients, the adjustment of their socio-demographic attributes with respect to this allele produced non-significant observations (Athan, Lee, Arriaga, Mayeux, and Tyco1797). Also, -9C allele was hardly detected for disease association.On the other hand, even though the adjustment with respect to socio-demographic traits was made, still a strong link was found between APOE allele and AD (Athan, Lee, Arriaga, Mayeux, and Tyco1797). Moreover, the evaluation of both +37C and -9C allele variants in U-87 glioma cells through promoter-reporter assays has resulted to non-significant promoter activity (Athan, Lee, Arriaga, Mayeux, and Tyco1797). The early onset, less than 60 years old, of AD has been ascribed to APP, PSEN1 and PSEN2 while the late stage, greater than 65 years old, AD development has not yet fully explained by the genetic model (Waring and Rosenberg 329).The development of AD in late age stage was associated with APOE and to other reported genetic variants and alleles, however, they still insufficient to plausibly explain the mechanism involved in the AD occurrence (Waring and Rosenberg 329). Summary Alzheimer ’s disease is a progressive degeneration of the capacity of the mind for cognition thus affecting the psychological and affective attributes of the inflicted individual.Based on genome-wide stu dy, children of parents with familial Alzheimer’s disease are more prone to inherit and develop this condition either as they take progress in their growth and development or at the senescence stage of their lives (Jayadev et. al. 375). The primary pointed culprit for this cognitive deterioration is the beta-amyloid peptide which is a part of amyloid precursor protein. APP passes through the fatty membrane of the cells and delineated in the different areas of the brain, even though, the normal function has not yet been fully known.As APP is attacked by enzymes, fragments are generated including A? -peptide with associated neurotoxicity. Sleegers et. al. in 2006 found the coincidence of cerebral amyloid angiopathy with Alzheimer’s disease in a Dutch multigenerational family. This genomic duplication was attributed solely to APP gene expression that was also observed in 65 Dutch families with early-onset of AD cases. However, APP locus duplication was not observed in 36 AD patients that signified the case of de novo mutation. On the other hand, Athan et. al.in 2002 reported the two types of APP promoter polymorphism which involved +37C and –9C alleles. Moreover, they found a strong link between AD inheritance and the apolipoprotein-E role. In this connection, the genetic traits of every individual should be scientifically scrutinized for an accurate determination and identification of the substance involved in the development of the disease in parallel with its molecular mechanisms. Works Cited Athan, Eleni S. , Lee, Joseph H. , Arriaga, Alex, Mayeux, Richard P. , and Tyco, Benjamin. â€Å"Polymorphism in the Promoter of the Human APP Gene.† Archives of Neurology 59 (2002): 1793-1799. Bloom, Elin. Genetic Studies of Alzheimer’s Disease. Acta Universitatis Upsaliensis. Uppsala, Sweden: Uppsala University, 2008. Felician, Olivier and Sandson, Thomas A. â€Å"The Neurobiology and Pharmacotherapy of Alzheimer’s Disease. â⠂¬  Journal of Neuropsychiatry and Clinical Neurosciences 11, 1 (1999): 19-31. Jayadev, Suman, Steinbart, Ellen J. , Chi, Yueh-Yun, Kukull, Walter A. , Schellenberg, Gerard D. and Bird, Thomas D. â€Å"Conjugal Alzheimer Disease. † Archives of Neurology 65, 3 (2008): 373-378.